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Rumble in the Northern Jungle

by Elixir on May 2nd, 2010 - Events, From the frontline, Industry News

canada

It’s good to be back POQing again after a small hiatus – nothing like a good POQ to get back into the swing of things.

The biggest news on the international pharmacy front seems to be the highly covered and sizzling situation boiling over in the province of Ontario in that giant country all tucked away up in the northerly direction of the States. That’s right, new legislation in the normally subdued and mild-mannered Canada has got both sides SEETHING with contempt on who will be to blame for what is expected to be the demise of independent pharmacy and to the fate of the pharmacy institution as a whole.

As was covered in one of the country’s most far reaching papers, The National Post, as well as numerous other hard copy and online news magazines (see here Macleans), the Ontario government as set in motion legislation that will put a cap on the allowable amount charged for generic medicines, that is pharmacies can now charge at maximum 25% of the brand name costs. The decision comes after literally years of budget review on how to decrease the annual millions spent by the government on drug costs – Ontario is the second largest medicines payer in North America and pays for medicines for seniors, the poor and many other social sectors. It should be noted, however,  that this legislation also limits the selling price to private payers, that is insurance companies or patients themselves.

The result, as it seems, is that Ontario pharmacies will suffer huge losses in revue, revenue that is used to staff pharmacists in the extensive hours that are now the norm and for services such as patient counselling, pill packs, and general pharmacy services that have come to be the norm, as it appears that pharmacies in this province gain significant revenues from increases in generic medicines sell-price as well as supplementation from the generic companies themselves for stocking certain products (read the full explanation in the Macleans article here).

OK, we all know there is a global economic crises but as a once-practicing pharmacist I am appalled by what I read in the Maclean’s article, MAINLY that these budget-cutting decisions were made by a politician who is NOT a pharmacist. What I find equally appalling is the unbreakable bond that societies and governments continue to make between the product of medicines and the practice of pharmacy – nowhere in this new legislation, it seems, were payment of patient services considered, public health influence or communicative aspects of the profession. It was merely the drugs, and that’s it. Are we still just the pill-pushers?  *shudder*

But, those recently mentioned services are what will be chopped from the pharmacy block when revenues dip, pharmacies cannot staff a sufficient amount of pharmacists nor stay open long hours. What the government failed to consider is that a large portion of those revenues went to subsidise these patient-centred services – are pharmacists expected to do it for free?

In my mind, this appears to be a huge step back for the profession in a country that is known for respectable and universal healthcare. I can’t pretend to know all the details but if I were a practitioner in an Ontario pharmacy, I’d be up in arms.

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These genes aren’t for sale

by Elixir on April 8th, 2010 - Events, From the frontline, Industry News

genome4A very interesting twist in legislation just happened in the US, one that will definitely set a precedent in the foreseen lengthy race between science and technology and the law.

Once again we have our friends at Wired to thank for bring us the story. As they so eloquently put it:  “When you went to sleep last Sunday night, 20 percent of your genome belonged to a researcher or company. One day later, following federal district court judge Robert Sweet’s ruling, it belonged to you”.

What has happened is that Federal Government in the US has put a ban on gene patents. That is, those companies that have invested billions of dollars sequencing certain sections of the human genome for drug/treatment development can no longer claim them under patent (and, therefore, hold a monopoly on studying that portion of the genome).

Although I honestly sympathise for the drug companies, in this particular case one called Myriad (even the National Public Radio was following the story…good times…) I more strongly lead towards Wired (and the general, common-sense equipped public) in that it is absurd to allow gene patents – no one created them, we have just discovered them. It’s like patenting a bad ex boyfriend – we feel like we are owed something for the years we spent trying to figure them out, yet can claim no proprietal rights. (Thankfully?).

So, now what? Some feal that this could cause competition within the biotech industry, resulting in a boon for patients. I myself think this is secondary and agree with another sector in that the focus must now be on using these gene discoveries to build new an innovative treatments,  further advance medical therapies and give patients real hope. Basically, as  Linda Avey, CEO of personalized genomics company 23andMe, says in her blog: “My hope is that this ruling stands and companies will need to actually innovate and create new advances based on genetic findings, not dependent on sole access to them”.

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Too many pharmacists, or too few roles?

by Elixir on March 28th, 2010 - From the frontline, Industry News

kangaroosI have just come across an article that is bold enough to admit that in a few years, there will likely be an oversupply of pharmacists (in this case in Australia, with a work force model predicting that there could be a surplus of 2,009 pharmacists in Australia within five years, rising to 2,594 by 2020 and 3,582 by 2025). Besides the fact that I think this trend will apply to far more countries than just Australia (more on that later) I find this a refreshing take on the argument that the health workforce supply is in dire straights all over the globe, mostly in rural and developing areas. Just because people don’t have access to the workforce, doesn’t mean it’s not there (I can see the hate mail already…).

Call me skeptical, but I find a global pharmacist shortage a hard pill to swallow (come on, this pun was in the mail from the very start of this blog!) …in fact the oversupply is a situation that any amount of common sense could have predicted for almost 10 years now, stemming from an under-supply generated by niche (and, as they were, transient) markets  followed  by an urgent push to graduate an increasing number of pharmacy professionals, in any case  in Canada and the US. At the time I graduated, bonuses were the norm, pharmacists could name their wage and hours and it was an employee market, to say the least, as pharmacies needed more pharmacists than there were. Now, from what I hear, bonuses are few and far between save for the very rural areas and graduates have a much more limited deck of cards to choose from.

However, this predicted predicament has prompted the Pharmacy Guild of Australia to take an interesting view, saying that this is the perfect opportunity for pharmacists to expand their roles beyond that of traditional pharmacy services. It’s a brilliant plan, which both defends the number of graduating pharmacists (rather than scaling them back) and opens the door for increased scope of practice.

There are inherent challenges of course, the most prominent being payment for such services. This calls on a shift of philosophy of reimbursement by healthcare payers – government, insurers, what-have-you. The second and perhaps more important is the shift in the general philosophy of the practice of pharmacy – future pharmacists would have to be aware that if they want to have a job after graduation, they may need to perform competently within circles that have normally been reserved for other allies on the healthcare team.

That being said, I like this approach. It raises the stakes for all and forces pharmacists to keep up with the times – stake their claim before it’s taken away!

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Banned Ads

by Elixir on March 7th, 2010 - From the frontline, Industry News, Patient Care

googleOver the past few years there has been considerable debate about direct-to-consumer advertising – banned in most countries, the US and New Zealand are the only two countries where patients/consumers are confronted with direct publicity regarding a certain drug/disease condition/cure/treatmet etc (such commercials have also become easy prey to satirical comedy shows like Saturday Night Live who love the fact that the commercials spend just as long listing the side effects as the benefits…legalities, I’m sure). The British Medical Journal has gone as far as to conduct research and publish articles on its influence on patients.

What has been less discussed, until now, is the issue of direct-to-consumer pharmacy advertising.  A non-issue for the most part – people go to their regular pharmacy OR the nearest pharmacy, that’s just the way it is. But, with the advent of online pharmacies and the inherent…differences (ie lack of personal interaction between the patient and pharmacist and legal credibility) they pose, things are cracking down.

HealthBusinessBlog was one of many to report Google’s crackdown on online pharmacy advertising in the US and Canada, stating that they will only post advertisiments for those online pharmacies registered under the Canadian International Pharmacy Association and the US National Association Boards of Pharmacy. Google AdWords are brief in their explanation but make it clear that the days free for all advertising of any and all online drug dealers, if I may use the words, are over.

What do I have to say about this? THANK YOU GOOGLE.  I worked for an  “online”  pharmacy during it’s economic and unrestricted renaissance and heyday about 10 years ago, and although my then employer was legit and did provide patients with less expensive medicines, there were undeniable, inherent problems.

The biggest of which came in the form of copycat pharmacies, which employed few if any pharmacists and in some cases contracted sub-par and (illegally) narcotic/restricted medicines, leading to sub-par treatments, abuse and in some cases, deaths.  In fact, our legally inclined friends in the US have even started a website on how to sue online pharmacies for malpractice, which somehow seems more in the spirit of capitalism than patient safety…but I digress.

There are more issues surrounding this issue than there is space for here, but  the reason why these online pharmacies still flourish I believe  is the direct result of two very key notions: 1. people value cheap medicines above any risk involved in online ordering and 2. we still have NOT made ourselves an invaluable, physical, moral and societal  connection between patients and medicines.

What’s it going to take?

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Blue Genes

by Elixir on February 7th, 2010 - From the frontline, Industry News

I am in no way an expert, but after reading an article called Gene Patents Under Legal Attack on Wired.com I have no reservations in saying that I think we are getting dangerously close tobeing in the centre of  brewing  Bermuda triangle of healthcare, where science and technology, law and ethics form a black hole of misunderstanding and mutual blockade to progression. dna21

The short history of genetics has told us that laws and ethics (if that is still a term you can apply to a vast number   of people who know little of emerging technology) are not keeping up with scientific advancements in healthcare, with many laws continually constrained by what I can only (and I only) call unacceptable and infuriating religious shackles (stem cell research to name just one example).  Wired brings  us a new example, this time with the sharp edge of capitalism thrown in.

The basic story is that a genetics company based in Utah is claiming patent rights on a pair of genes they discovered that are closely related to breast and ovarian cancer. The patent basically prevents any other body/organisation from studying the genes, including those that would develop diagnostic tests for gene malfunctioning; that is, in essence, predicting/preventing cancer.  In as such,  the company holds a monopoly on the genes and all associated research.

And, as such, they are being sued.  A conglomerate group of plaintiffs (compiled of such high level organisations as the American Medical Association,  the American Society of Human Genetics and the March of Dimes, which along with their fellow plaintiff organisations represent over 150 000 researchers) claim that such patents prevent further research on the genes which may uncover more and better treatments, cures, preventative measures and any and all within the discoverable realm of gene therapy.

The company’s request for dismissal was, well dismissed. They are arguing that patents and ownership must stay in place to sustain and foster the commercial aspect of the biotechnology industry; the plaintiffs countered with a 1931 ruling that the American Fruit Industry didn’t actually own the patent on the fruit, being a naturally occuring phenomenon. As Wired points out, the fruit industry has not suffered.

It will be interesting to see how this plays out over the next months, especally considering the somewhat-new US Administration. I also claim to be no expert on politics, but I am convinced that a Bush government would side for commercial and industrial gain rather than extended scientific discovery for the sake of more saved lives.

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Does HIV/AIDS really exist?

by Elixir on January 19th, 2010 - From the frontline, Industry News

There are some who say NO. Can you even believe it? At this particular moment I caparagon-studios-remixes-house-of-numbersn’t…I even find the concept of people supporting a “myth”   of  HIV/AIDS horrifying, a callback to the early days when lagging scientific research and homophobia clouded a true understanding of the disease, its origins and its prevention.

But I was just sent a link to a new documentary that is causing a stir in both the medical and entertainment industry. It’s called House of Numbers and launches itself at an audience with an introduction so provocative one can’t help but be intrigued:

In House of Numbers, an AIDS film like no other, the HIV/AIDS story is being rewritten. This is the first film to present the uncensored POVs of virtually all the major players; in their own settings, in their own words. It rocks the foundation upon which all conventional wisdom regarding HIV/AIDS is based. House of Numbers could well be the opening volley in a battle to bring sanity and clarity to an epidemic gone awry.

The trailer does not reveal much but left me both frightened and questioning society’s attention to the matter  – can they actually expect both the lay public and a global collection of health professionals to believe that HIV/AIDS is not the killer we have been lead to believe? And if it is not, why and how has it grown to be the demon it is?

The awards this film has garnished are way too numerous to mention here, and needless to say I can’t wait to see the movie, although with limited screenings I may have to go to Hawaii (I fail to see the problem).

To be honest,  I’m of open enough mind to entertain the idea that what they are saying is in fact true, that the numbers of HIV infected are spin doctored for political reasons, that other factors play a much more significant role in the death of HIV+ patients than the virus itself – talk to me about it, as an educated person, I’m listening.

What I hope NO ONE regrets, however, is the awareness that these letters  have brought to the world regarding sexual health – no other disease in history has asked generations of the global community to be more careful, to take only the best care of themselves AND those around them.

And myth or not, I invite anyone to challenge that.

View the trailer on the website or at Apple Trailers by clicking here

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Placebo vs Big Pharma

by Elixir on January 6th, 2010 - From the frontline, Industry News, Medicines

I just read a fascinating article on Wired.com called Placebos Are Getting More Effective. Drugmakers Are Desperate to Know Why.  The basic point was that the placebo effect, ie the phenomenon of patients recovering from illness when given “fake” pills rather than real ones (or, as studies show, even anticipating taking medicines), has grown so significantly over the past 20 years that Big Pharma, in all their glory, is shaking in their well-heeled boots.

The article cites numerous examples of  new medicines are being stopped in Phase 1 and Phase 2 Clinical trials because they have not shown a statistically significant improvement in curing disease over the placebo medicines; a method of measuring effectiveness known as the randomised, controlled double-blind clinical trial borne in the 1950’s by anesthetist Henry Beplacebo.echer, a WWII doctor turned researcher who witnessed a wounded soldier find relief from a syringe of saline solution when told it was morphine.

The placebo effect is nothing new, we have all heard about it and I would say most believe in it. What IS new is that the worlds of drug research, development, trials and marketing are now considering the placebo effect a real threat to the release of new medicines; the US FDA will not release a medicine for use if it has not beaten placebo in two trials.

And, why should they? Why should patients take medicines when they can heal themselves?  Ah if it were only so simple. What I find most fascinating in the article, as a scientist, pharmacist and patient alike, is the conditions under which the placebo effect is most, well, effective. As Wired extensively goes on to explain, the  rise of  unaware self-healing has paralleled the rise in medicines  manipulating complex neurological functions – those that regulate mood, happiness, well-being and in reverse those whose malfunction cause depression, anxiety and other detrimental psychiatric disorders. The author goes so far as to  suggest that blockbusters like Prozac, which has achieved record breaking, billion dollar sales  for Eli Lilly in ‘curing’  depression, may not truly fair significantly better than placebo.

But it was not just the fake meds themselves, it was the act of taking the medicine, the demeanor of the health care providers around them, and the inherent HOPE of getting better that was often as much to do with the healing as the little sugar pills themselves.

What does this say to us? Well, I still firmly believe that medicines should be taken when medicines are needed – as Wired says, no one will dispute the fact that anthracycline shrinks cancerous tumours. But what it speaks to is our incredible ability as humans to make ourselves better, given the right circumstances…and sometimes just the right coloured capsule.

Read the full article at Wired.com here

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